Toxicology studies have identified pregnancy as a window of susceptibility for endocrine disrupting chemicals (EDCs) and cardiometabolic indices in women. No study in humans, however, has examined EDC mixtures and cardiometabolic indices during pregnancy. The Health Outcomes and Measures of the Environment (HOME) Study was used to examine whether EDCs bisphenol A (BPA), polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFAS), and phthalates were associated with blood pressure, glucose, and lipids in 388 pregnant women. There were positive associations between PBDEs with glucose and cholesterol levels. No relationship was noted for BPA or PFAS with cardiometabolic indices.