Publications

2022

  • Zekri Y, Guyot R, Suñer IG, Canaple L, Stein AG, Petit JV, Aubert D, Richard S, Flamant F, Gauthier K. (2022). Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice. Elife 11: e81996.

DOI: https://doi.org/10.7554/eLife.81996

  • Zekri Y, Guyot R, and Flamant F. (2022). An Atlas of Thyroid Hormone Receptors’ Target Genes in Mouse Tissues. International Journal of Molecular Sciences 23(19): 11444.

DOI: https://doi.org/10.3390/ijms231911444

  • Tribondeau, A., Sachs, L.M. and Buisine, N. (2022). Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system. Frontiers in Genetics 13:996826.

DOI: https://doi.org/10.3389/fgene.2022.996826

  • Gölz, L., Baumann, L., Pannetier, P., Braunbeck, T., Knapen, D., and Vergauwen, L. (2022). AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish via Altered Retinal Layer Structure. Environmental Toxicology and Chemistry.

DOI: https://doi.org/10.1002/etc.5452

Repository link coming soon

  • Davidsen, N., Ramhøj, L., Lykkebo, C.A., Kugathas, I., Poulsen, R., Rosenmai, A.K., Evrard, B., Darde., T.A., Axelstad, M., Bahl, M.I., Hansen, M., Chalmel, F., Licht, T.R. and Svingen, T. (2022). PFOS-Induced Thyroid Hormone System Disrupted Rats Display Organ-Specific Changes in Their Transcriptomes. Environmental Pollution, p.119340

DOI: https://doi.org/10.1016/j.envpol.2022.119340

Repository link

  • Flamant, F., Zekri, Y. and Guyot, R. (2022). Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen. Endocrinology, 163 (8).

DOI: https://doi.org/10.1210/endocr/bqac084

Link to publication

Supplementary data coming soon

  • Affortit, C., Blanc, F., Nasr, J., Ceccato, J.C., Markossian, S., Guyot, R., Puel, J.L., Flamant, F. and Wang, J. (2022). A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice. Science signaling15 (738), eabj4583.

DOI: https://doi.org/10.1126/scisignal.abj4583

  • Bidisha, P., Sterner, Z.R., Buchholz, D.R., Shi, Y.B. and Sachs, L.M. (2022). Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis. Cells 11, no. 10: 1595.

DOI: https://doi.org/10.3390/cells11101595

  • Morthorst, J., Holbech, H., de Crozé, N., Matthiessen, P., and LeBlanc, G. (2022). Thyroid‐like hormone signalling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals. Integrated Environmental Assessment and Management.

DOI: https://doi.org/10.1002/ieam.4632

  • Hamdaoui, Q., Zekri, Y., Richard, S., Aubert, D., Guyot, R., Markossian, S., Gauthier, K., Gaie-Levrel, F., Bencsik, A., & Flamant, F. (2022). Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain. Chemosphere, 287, 132253.

DOI: https://doi.org/10.1016/j.chemosphere.2021.132253

  • Maranaa, M.H., Poulsen, R., Thormar, E.A., Clausen, C.G., Thitd, A., Mathiessen, H., Jaafar, R., Korbut, R., Magdalene, A., Hansen, B., Hansen, M., Limborg, M.T., Syberg, K., von Gersdorff Jørgensen, L. (2022). Plastic Nanoparticles Cause Mild Inflammation, Disrupt Metabolic Pathways, Change the Gut Microbiota and Affect Reproduction in Zebrafish: A Full Generation Multi-Omics Study. Journal of Hazardous Materials, vol. 424, p. 127705.

DOI: https://doi.org/10.1016/j.jhazmat.2021.127705

Repository of metabolomics data coming soon.

2021

  • Svingen, T., Villeneuve, D. L., Knapen, D., Panagiotou, E. M., Draskau, M. K., Damdimopoulou, P., & O’Brien, J. M. (2021). A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation. Toxicological Sciences, 184(2), 183–190.

DOI: https://doi.org/10.1093/toxsci/kfab113

  • Audouze, K., Zgheib, E., Abass, K., Baig, A., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P., Lupu, D., Palaniswamy, S., Rautio, A., Sapounidou, M. and Martin, O. (2021). Evidenced-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities. Frontiers in Toxicology.

DOI: https://doi.org/10.3389/ftox.2021.787017

  • Kratochvíl, L., Stöck, M., Rovatsos, M., Bullejos, M., Herpin, A., Jeffries, D.L., Peichel, C.L., Perrin, N., Valenzuela, N. and Johnson Pokorná, N. (2021). Expanding the Classical Paradigm: What We Have Learnt from Vertebrates about Sex Chromosome Evolution. Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, p. 20200097.

DOI: https://doi.org/10.1098/rstb.2020.0097

Repository link

  • Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K. (2021). Sex Chromosomes in Meiotic, Hemiclonal, Clonal and Polyploid Hybrid Vertebrates: Along the ‘Extended Speciation Continuum. Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, p. 20200103.

DOI: https://doi.org/10.1098/rstb.2020.0103

Repository link

  • Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K. (2021). Sex chromosomes in so-called “asexual” hybrid vertebrates: along the ‘extended speciation continuum’. European Society of Evolutionary Biology (ESEB) Satellite Symposium Genomic signatures and consequences of sex and asexuality 16.06.2021 – 17.06.2021, all times indicated are CEST Hosts Astrid Böhne, ZFMK and Philipp Schiffer, University of Cologne. 

Repository link: https://uni-koeln.sciebo.de/s/lPnizXkgzJcCQnz

  • Rousseau, K., Dufour, S. and Sachs, L. M. (2021). Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions. Frontiers in Ecology and Evolution, 9.

DOI: https://doi.org/10.3389/fevo.2021.735487

  • Zekri, Y., Agnol, L.D, Flamant, F. and Guyot, R. (2021). In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors. iScience, 102957.

DOI: https://doi.org/10.1016/j.isci.2021.102957

  • Steinbach, A.M. (2021). Mechanistic evaluation of rodent studies for selected thyroid disrupting chemicals (TDCs). From key events to adverse outcome pathway. (Unpublished Master’s thesis). University of Milan and BASF SE.

Master Thesis_Steinbach (2021)

  • Zekri, Y., Flamant, F., & Gauthier, K. (2021). Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic. Cells, 10(6), 1327.

DOI: https://doi.org/10.3390/cells10061327

Repository link: https://www.mdpi.com/2073-4409/10/6/1327/htm

  • Kubickova, B., Ramwell, C., Hilscherova, K. and Jacobs, M.N. (2021). Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study. Environmental Sciences Europe 33, 20.

DOI: https://doi.org/10.1186/s12302-020-00428-0

2020

  • Knapen, D., Stinckens, E., Cavallin, J., Ankley, G., Holbech, H., Villeneuve, D. and Vergauwen, L. (2020). Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption. Environmental Science & Technology, 54(14), pp. 8491−8499.

DOI: https://doi.org/10.1021/acs.est.9b07205.

Publication repository

Data repository – Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki): AOP IDs: 155-159, 363-365

  • Stinckens, E., Vergauwen, L., Blackwell, B., Ankley, G., Villeneuve, D. and Knapen, D. (2020). Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish. Environmental Science & Technology, 54(10), pp.6213-6223.

DOI: https://doi.org/10.1021/acs.est.9b07204

Repository link 1

Repository link 2

  • Holbech, H.; Matthiessen, P.; Hansen, M.; Schüürmann, G.; Knapen, D.; Reuver, M.; Flamant, F.; Sachs, L.; Kloas, W.; Hilscherova, K.; Leonard, M.; Arning, J.; Strauss, V.; Iguchi, T.; Baumann, L. (2020). ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters. International Journal of Molecular Sciences, 21: 2954.

DOI: https://doi.org/10.3390/ijms21082954

  • Richard S, Guyot R, Rey-Millet M, Prieux M, Markossian S, Aubert D and Flamant F. (2020). A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons. iScience 23 (3): 100899.

DOI: 10.1016/j.isci.2020.100899

Data repository – Genome Expression Omnibus (GEO): series accession number: GSE143933