Publications

2024

  • Pesce, E., De Los Monteros Garde, M. J. E., Rigolet, M., Tindall, A. J., Lemkine, G. F., Baumann, L. A., Sachs, L. M., & Du Pasquier, D. (2024). A novel transgenic model to study thyroid axis activity in early life stage Medaka. Environmental Science & Technology 58 (1), 99-109.

DOI: https://doi.org/10.1021/acs.est.3c05515

Repository link

Supplementary materials: Videos and Methods

  • Volz, S. N., Poulsen, R., Hansen, M., & Holbech, H. (2024). Bisphenol A alters retinal morphology, visually guided behavior, and thyroid hormone levels in zebrafish larvae. Chemosphere, 348, 140776.

DOI: https://doi.org/10.1016/j.chemosphere.2023.140776

  • Kühne, R., Hilscherová, K., Smutná, M., Leßmöllmann, F., & Schüürmann, G. (2024). In silico bioavailability triggers applied to direct and indirect thyroid hormone disruptors. Chemosphere, 140611.

DOI: https://doi.org/10.1016/j.chemosphere.2023.140611

2023

  • Poulsen R, Zekri Y, Guyot R, Flamant F & Hansen M. (2023). Effect of in utero and lactational exposure to a thyroid hormone system disrupting chemical on mouse metabolome and brain transcriptome. Environmental  Pollution 1;340 (Pt 2):122783.

DOI: https://doi.org/10.1016/j.envpol.2023.122783

  • OECD (2023), Detailed Review Paper (DRP) on the thyroid hormone system in fish and identification of potential thyroid hormone system related endpoints for inclusion in existing OECD fish Test Guidelines, OECD Series on Testing and Assessment, No. 381, OECD Publishing, Paris, https://one.oecd.org/document/ENV/CBC/MONO(2023)17/en/pdf.

The DRP is a supporting document for OECD Project 2.64 (inclusion of thyroid hormone system sensitive endpoints into existing OECD fish TGs), and will be used as guidance in the upcoming validation of the first four thyroid hormone system disruption (THSD) endpoints in fish tests.

  • Haigis, A., Vergauwen, L., LaLone, C. A., Villeneuve, D. L., O’Brien, J. M., & Knapen, D. (2023). Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption. Toxicological Sciences.

DOI: https://doi.org/10.1093/toxsci/kfad063. Embargo period: 12 months.

  • Poulsen, R., Jackman, S. H., Hansen, M., & Helbing, C. C. (2023). Relationship between serum thyroid hormones and their associated metabolites, and gene expression bioindicators in the back skin of Rana [Lithobates] catesbeiana tadpoles and frogs during metamorphosis. Frontiers in Endocrinology13.

DOI: https://doi.org/10.3389/fendo.2022.1103051

Repository link

  • Van Dingenen, I., Vergauwen, L., Haigis, A., Blackwell, B. R., Stacy, E., Villeneuve, D. L., & Knapen, D. (2023). Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish. Aquatic Toxicology261, 106632.

DOI: https://doi.org/10.1016/j.aquatox.2023.106632. Embargo period: 24 months.

  • Jensen, M., Poulsen, R., Langebæk, R., Jenssen, B. M., Moe, J. M., Ciesielski, T. M., Dietz, R., Sonne, C., Madsen, J., & Hansen, M. (2023). The metabolome of pink-footed goose: Heavy metals and lipid metabolism. Environmental Research231, 116043.

DOI: https://doi.org/10.1016/j.envres.2023.116043

Repository link

  • Pannetier, P., Poulsen, R., Gölz, L., Coordes, S., Stegeman, H., Koegst, J., Reger, L., Braunbeck, T., Hansen, M. R. H., & Baumann, L. (2023). Reversibility of thyroid hormone system‐disrupting effects on eye and thyroid follicle development in zebrafish (Danio rerio) embryos. Environmental Toxicology and Chemistry42(6), 1276–1292.

DOI: https://doi.org/10.1002/etc.5608

  • Ramhøj, L., Guyot, R., Svingen, T., Kortenkamp, A., Flamant, F. and Axelstad, M. (2023). Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies? Regulatory Toxicology and Pharmacology142, 105445.

DOI: https://doi.org/10.1016/j.yrtph.2023.105445

  • Flamant, F. and Ren, J. (2023). Thyroid hormone as a temporal switch in mouse development. European Thyroid Journal, 12(2).

DOI: https://doi.org/10.1530/etj-22-0225

  • Horie, Y., Yamagishi, T., Yamamoto, J., Suzuki, M., Onishi, Y., Chiba, T., Miyagawa, S., Lange, A., Tyler, C. R., Okamura, H., & Iguchi, T. (2023). Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes). Comparative Biochemistry and Physiology C-toxicology & Pharmacology263, 109502.

DOI: https://doi.org/10.1016/j.cbpc.2022.109502

Repository link

  • Kraft, M., Gölz, L., Rinderknecht, M., Koegst, J., Braunbeck, T. and Baumann, L. (2023). Developmental exposure to triclosan and benzophenone-2 causes morphological alterations in zebrafish (Danio rerio) thyroid follicles and eyes. Environmental Science and Pollution Research 30, 33711–33724.

DOI: https://doi.org/10.1007/s11356-022-24531-2

2022

  • Vergauwen, L., et al. (2022), “Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation”, OECD Series on Adverse Outcome Pathways, No. 22, OECD Publishing, Paris.

DOI: https://doi.org/10.1787/dc406014-en.

Repository link

  • Vergauwen, L., et al. (2022), “Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation”, OECD Series on Adverse Outcome Pathways, No. 23, OECD Publishing, Paris.

DOI: https://doi.org/10.1787/b1bf0bea-en.

Repository link

  • Vergauwen, L., et al. (2022), “Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation”, OECD Series on Adverse Outcome Pathways, No. 24, OECD Publishing, Paris.

DOI: https://doi.org/10.1787/9cb525e9-en.

Repository link

  • Vergauwen, L., et al. (2022), “Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation”, OECD Series on Adverse Outcome Pathways, No. 25, OECD Publishing, Paris.

DOI: https://doi.org/10.1787/9f651c16-en.

Repository link.

  • Vergauwen, L., et al. (2022), “Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation”, OECD Series on Adverse Outcome Pathways, No. 26, OECD Publishing, Paris.

DOI: https://doi.org/10.1787/447c5cba-en.

Repository link.

  • Horie, Y., Nomura, M., Okamoto, K., Takahashi, C., Sato, T., Miyagawa, S., Okamura, H., & Iguchi, T. (2022). Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish. Journal of Applied Toxicology42(8), 1385–1395.

DOI: https://doi.org/10.1002/jat.4302

Repository link

  • Fjære, Even, Rikke Poulsen, Arne Duinker, Bjørn Liaset, Martin Hansen, Lise Madsen, and Lene Secher Myrmel. (2022). Iodine Bioavailability and Accumulation of Arsenic and Cadmium in Rats Fed Sugar Kelp (Saccharina latissima). Foods 11, no. 24: 3943.

DOI: https://doi.org/10.3390/foods11243943

  • Zekri Y, Guyot R, Suñer IG, Canaple L, Stein AG, Petit JV, Aubert D, Richard S, Flamant F, Gauthier K. (2022). Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice. Elife 11: e81996.

DOI: https://doi.org/10.7554/eLife.81996

  • Zekri Y, Guyot R, and Flamant F. (2022). An Atlas of Thyroid Hormone Receptors’ Target Genes in Mouse Tissues. International Journal of Molecular Sciences 23(19): 11444.

DOI: https://doi.org/10.3390/ijms231911444

Repository link

  • Tribondeau, A., Sachs, L.M. and Buisine, N. (2022). Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system. Frontiers in Genetics 13:996826.

DOI: https://doi.org/10.3389/fgene.2022.996826

  • Gölz, L., Baumann, L., Pannetier, P., Braunbeck, T., Knapen, D., and Vergauwen, L. (2022). AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish via Altered Retinal Layer Structure. Environmental Toxicology and Chemistry.

DOI: https://doi.org/10.1002/etc.5452

Repository link

  • Davidsen, N., Ramhøj, L., Lykkebo, C.A., Kugathas, I., Poulsen, R., Rosenmai, A.K., Evrard, B., Darde., T.A., Axelstad, M., Bahl, M.I., Hansen, M., Chalmel, F., Licht, T.R. and Svingen, T. (2022). PFOS-Induced Thyroid Hormone System Disrupted Rats Display Organ-Specific Changes in Their Transcriptomes. Environmental Pollution, p.119340

DOI: https://doi.org/10.1016/j.envpol.2022.119340

Repository link

  • Flamant, F., Zekri, Y. and Guyot, R. (2022). Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen. Endocrinology, 163 (8).

DOI: https://doi.org/10.1210/endocr/bqac084

Link to publication

Repository link – supplementary data

  • Affortit, C., Blanc, F., Nasr, J., Ceccato, J.C., Markossian, S., Guyot, R., Puel, J.L., Flamant, F. and Wang, J. (2022). A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice. Science signaling15 (738), eabj4583.

DOI: https://doi.org/10.1126/scisignal.abj4583

  • Bidisha, P., Sterner, Z.R., Buchholz, D.R., Shi, Y.B. and Sachs, L.M. (2022). Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis. Cells 11, no. 10: 1595.

DOI: https://doi.org/10.3390/cells11101595

  • Morthorst, J., Holbech, H., de Crozé, N., Matthiessen, P., and LeBlanc, G. (2022). Thyroid‐like hormone signalling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals. Integrated Environmental Assessment and Management.

DOI: https://doi.org/10.1002/ieam.4632

  • Hamdaoui, Q., Zekri, Y., Richard, S., Aubert, D., Guyot, R., Markossian, S., Gauthier, K., Gaie-Levrel, F., Bencsik, A., & Flamant, F. (2022). Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain. Chemosphere, 287, 132253.

DOI: https://doi.org/10.1016/j.chemosphere.2021.132253

  • Maranaa, M.H., Poulsen, R., Thormar, E.A., Clausen, C.G., Thitd, A., Mathiessen, H., Jaafar, R., Korbut, R., Magdalene, A., Hansen, B., Hansen, M., Limborg, M.T., Syberg, K., von Gersdorff Jørgensen, L. (2022). Plastic Nanoparticles Cause Mild Inflammation, Disrupt Metabolic Pathways, Change the Gut Microbiota and Affect Reproduction in Zebrafish: A Full Generation Multi-Omics Study. Journal of Hazardous Materials, vol. 424, p. 127705.

DOI: https://doi.org/10.1016/j.jhazmat.2021.127705

Supplementary material

2021

  • da Silva, Katyeny Manuela, Elias Iturrospe, Chloe Bars, Dries Knapen, Steven Van Cruchten, Adrian Covaci, and Alexander L. N. van Nuijs. (2021). Mass Spectrometry-Based Zebrafish Toxicometabolomics: A Review of Analytical and Data Quality Challenges. Metabolites 11, no. 9: 635.

DOI: https://doi.org/10.3390/metabo11090635

  • Svingen, T., Villeneuve, D. L., Knapen, D., Panagiotou, E. M., Draskau, M. K., Damdimopoulou, P., & O’Brien, J. M. (2021). A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation. Toxicological Sciences, 184(2), 183–190.

DOI: https://doi.org/10.1093/toxsci/kfab113

  • Audouze, K., Zgheib, E., Abass, K., Baig, A., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P., Lupu, D., Palaniswamy, S., Rautio, A., Sapounidou, M. and Martin, O. (2021). Evidenced-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities. Frontiers in Toxicology.

DOI: https://doi.org/10.3389/ftox.2021.787017

  • Kratochvíl, L., Stöck, M., Rovatsos, M., Bullejos, M., Herpin, A., Jeffries, D.L., Peichel, C.L., Perrin, N., Valenzuela, N. and Johnson Pokorná, N. (2021). Expanding the Classical Paradigm: What We Have Learnt from Vertebrates about Sex Chromosome Evolution. Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, p. 20200097.

DOI: https://doi.org/10.1098/rstb.2020.0097

Repository link

  • Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K. (2021). Sex Chromosomes in Meiotic, Hemiclonal, Clonal and Polyploid Hybrid Vertebrates: Along the ‘Extended Speciation Continuum. Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, p. 20200103.

DOI: https://doi.org/10.1098/rstb.2020.0103

Repository link

Supplementary data – Table S1

Supplementary data – Table S2

  • Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K. (2021). Sex chromosomes in so-called “asexual” hybrid vertebrates: along the ‘extended speciation continuum’. European Society of Evolutionary Biology (ESEB) Satellite Symposium Genomic signatures and consequences of sex and asexuality 16.06.2021 – 17.06.2021, all times indicated are CEST Hosts Astrid Böhne, ZFMK and Philipp Schiffer, University of Cologne. 

Repository link: https://uni-koeln.sciebo.de/s/lPnizXkgzJcCQnz

  • Rousseau, K., Dufour, S. and Sachs, L. M. (2021). Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions. Frontiers in Ecology and Evolution, 9.

DOI: https://doi.org/10.3389/fevo.2021.735487

  • Zekri, Y., Agnol, L.D, Flamant, F. and Guyot, R. (2021). In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors. iScience, 102957.

DOI: https://doi.org/10.1016/j.isci.2021.102957

  • Steinbach, A.M. (2021). Mechanistic evaluation of rodent studies for selected thyroid disrupting chemicals (TDCs). From key events to adverse outcome pathway. (Unpublished Master’s thesis). University of Milan and BASF SE.

Master Thesis_Steinbach (2021)

  • Zekri, Y., Flamant, F., & Gauthier, K. (2021). Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic. Cells, 10(6), 1327.

DOI: https://doi.org/10.3390/cells10061327

Repository link

  • Kubickova, B., Ramwell, C., Hilscherova, K. and Jacobs, M.N. (2021). Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study. Environmental Sciences Europe 33, 20.

DOI: https://doi.org/10.1186/s12302-020-00428-0

2020

  • Knapen, D., Stinckens, E., Cavallin, J., Ankley, G., Holbech, H., Villeneuve, D. and Vergauwen, L. (2020). Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption. Environmental Science & Technology, 54(14), pp. 8491−8499.

DOI: https://doi.org/10.1021/acs.est.9b07205.

Publication repository

Data repository – Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki): AOP IDs: 155-159, 363-365

  • Stinckens, E., Vergauwen, L., Blackwell, B., Ankley, G., Villeneuve, D. and Knapen, D. (2020). Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish. Environmental Science & Technology, 54(10), pp.6213-6223.

DOI: https://doi.org/10.1021/acs.est.9b07204

Repository link 1

Repository link 2

  • Holbech, H.; Matthiessen, P.; Hansen, M.; Schüürmann, G.; Knapen, D.; Reuver, M.; Flamant, F.; Sachs, L.; Kloas, W.; Hilscherova, K.; Leonard, M.; Arning, J.; Strauss, V.; Iguchi, T.; Baumann, L. (2020). ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters. International Journal of Molecular Sciences, 21: 2954.

DOI: https://doi.org/10.3390/ijms21082954

  • Richard S, Guyot R, Rey-Millet M, Prieux M, Markossian S, Aubert D and Flamant F. (2020). A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons. iScience 23 (3): 100899.

DOI: 10.1016/j.isci.2020.100899

Data repository – Genome Expression Omnibus (GEO): series accession number: GSE143933