International Akademie Fresenius Conference

Regulatory Toxicology of Active Substances in Plant Protection Products

In vitro comparative metabolism studies

• Development of adverse outcome pathways (AOP)
• In vitro screening battery

Cumulative assessment and combined exposure

• Cumulative assessment groups and tools used to draft scientific reports
• Dietary and non-dietary combined risk assessment

QSAR and read-across

• Assessment of genotoxicity and general toxicity of metabolites in residues
• Use of in silico tools

Genotoxicity of active substances

• Hurdles and challenges
• In vivo comet assay

Impurities

• Impurity profiles of active substance

Evaluation of public literature

• Relevance and reliability
• SciRAP tool

Benchmark dose modelling

• Current state of the approach
• Regulatory use