3rd International Akademie Fresenius MIXTOX Conference

Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment

Risk Management and Communication

• EU Commission on risk management approaches in assessing the cumulative risk of combined dietary exposure to pesticide residues
• Health Canada on their cumulative health risk assessment approach for pesticides
• Lay people’s toxicology and how heuristics influence perceptions

Risk Assessment

• Latest activities of JMPR and JECFA
• OECD document on assessing the risks of combined exposures to multiple chemicals and way forward
• Industry activities on cumulative risk assessment of pesticide residues

Exposure Assessment

• Probabilistic exposure modelling in cosmetics, pesticides and food
• Ineris: PBPK modelling for assessing exposure to chemical mixtures
• An exposome approach to mixtures

Hazard Assessment

• Grouping active substances in cumulative assessment groups – EFSA and ECPA approach
• Using (Q)SARs, TTC, molecular docking simulation and read-across
• Mixture effects at low doses and implications for biomonitoring and risk assessments in regulatory practice