The Institute of Functional Genomics of Lyon (IGFL) is a research unit of ENSL, a prestigious elite French public institution that trains professors, researchers, senior civil servants as well as business and political leaders. IGFL is supported by CNRS, the Université Claude Bernard Lyon 1 and the National Institute for Agronomical Research (INRA). It gathers more than 100 members organised into 15 independent groups from different backgrounds. The IGFL’s originality comes from bringing together embryologists, endocrinologists, specialists in bioinformatics, evolutionary scientists, palaeontologists, physiologists and genome specialists. It is the Functional Genomics of Thyroid Hormone Receptors Group that will be most involved in ERGO. The group have six permanent members and their research is dedicated to the understanding of thyroid hormone signalling in vivo, with a specific interest in the mammalian brain. The group received international recognition for its genetic investigation of the neurodevelopmental function of the nuclear receptors of thyroid hormone, which heavily relies on expertise in transgenic mice technology, developed on an in-house platform. It continues to address basic questions on the mechanisms underlying the neurodevelopmental function of thyroid hormone. The group has also been a pioneer in toxicogenomics, applying advanced genomic technology to the field of thyroid hormone disruptors. It has been repeatedly funded by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) to develop innovative tools to study endocrine disruptors.