CNRS was founded in 1939 and is a state-funded science and technology establishment placed under the authority of the French Minister for Research and Higher Education. Laboratory Evolution des régulations endocriniennes (UMR 7221) is a joint research unit under the umbrella of several establishments, including CNRS and the Muséum National d’Histoire Naturelle (MNHN). Several MNHN employees are involved in the ERGO project. MNHN is a museum and research centre created in 1635, with the mission to make knowledge about the natural world accessible to everyone and to make as many people as possible aware of the importance of protecting our planet. The main objective of the research unit is now to understand the physiological regulations that control development, tissue homeostasis, regeneration and aging in normal and altered conditions. The unit focuses on how the modulation of gene regulatory networks mainly through thyroid hormone signalling contributed to the evolution and generation of biodiversity and how these regulatory processes might be affected by disruption. The group’s objective is to determine the physiological consequences of exposure to endocrine disruptors and environmental changes related to stress and life cycle transitions. The team develops four axes of research: 1) the evolution of molecular control of life cycle transitions with a special emphasis on amphibian metamorphosis, a post-embryonic developmental process that is linked to change of environment, controlled by environmental challenges and initiated by thyroid hormones, 2) the control of cell fate plasticity by thyroid hormones, 3) the impact of endocrine disruptors on thyroid signalling, and 4) the interaction between thyroid hormone signalling and glucocorticoid signalling, one of the mediator of stress and environmental changes.